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Mar 22

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CALMODULIN

Calmodulin (CaM) (an abbreviation for CALcium-MODULated proteIN) is a calcium-binding messenger protein expressed in all eukaryotic cells

 Calmodulin is a small, protein approximately 148 amino acids long, and is dumb bell shaped protein with its N and C terminals domains joined by a central helix.

each domain had two high effinity Calcium binding sites.

Binding of calcium to these sites causes conformationation chages in calmodulin. due to these conformationation changes , calmodulin binds tighly to the target protein.

CaM mediates many crucial processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, and the immune response.

 some important enzymes activated by binding of Ca to calmodulin are

  1.  adenyl cyclase- coversion of ATP- AMP
  2.  Calcium dependent protein kinases : many signaling cascades and is thought to be an important mediator of learning and memory, Immune signalling
  3. Ca Mg ATPase : regulating the amount of Ca2+ within cells
  4. Glycogen sythase- is an enzyme involved in converting glucose to glycogen
  5. Myosin Kinase: important in the contraction in muscle
  6. Phospholipase-C- enzymes that cleave phospholipids- important in signal transduction.
  7. Pyruvate dehydrogenase: transforming pyruvate into acetyl-CoA

 

About the author

dr_swati

dr_swati

Dr Swati Pradeep Patel , is MDS (Periodontics) from GDC, Bagalore, a Gold Medalist, currently Pursuing Ph.D at RGUHS. She has secured top ranks in various entrances, including AIPG, COMEDK, MHCET, PGI.
She loves teaching and fortunately could make it a profession. She is Academic adviser and faculty at AIM MDS.

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